For years, I’ve been testing clients for the MTHFR gene snp, especially if they don’t respond as expected to Neuro Nutrition (the use of therapeutic doses of amino acids to restore neurotransmitter levels in the brain).
An MTHFR polymorphism (snp) is a common gene mutation that causes a key enzyme in the body to function at a lower rate than normal. This leads to compromised methylation by every cell in your body, which can mean a compromised ability to detox toxins you are exposed to and a stressed liver due to this toxic overload.
I never took the test myself.
I had OUTSTANDING success using Neuro Nutrition years ago to eliminate my anxiety, depression, panic and mood issues . . . so . . . I thought I was good.
A recent diagnosis (bump) forced me to revisit this issue and realize this polymorphism is likely a MAJOR contributor to the cells gone wild in my breast. (I say likely as I’m awaiting my test results.)
From a Dutch Hormone Panel I took a year ago, and with the help of my Dr. at Hope 4 Cancer, I was able to see that although my estrogen levels looked fine, my estrogen metabolites indicated low methylation likely caused by genetic abnormalities. Estrogen is metabolized primarily by the liver and my metabolism ratios were low indicating compromise in my Methylation Pathways which can tax the liver and contribute to many diseases including breast cancer.
If you look at this picture below of The Methylation Pathways, you’ll see how incredibly complex and individual this function of our body is. There’s no way I could address a one size fits all assessment or recommendation for methylation issues in a blog. My intent here, therefore, is to make you aware of the implications and encourage you to invest in testing if anything resonates with you.
MTHFR stands for methyl-tetrahydrofolate reductase, an enzyme that is responsible for the process of methylation in every cell in your body. Methylation is a core process in all cells that helps your body properly make biochemicals reactions and “products” of those reactions which are needed for the next biochemical reaction in the pathway. And our bodies are nothing but a giant collection of biochemical reactions! There are over 50 known MTHFR variants which can be determined by a blood test (2 primary ones are C677T and A1298).
Methylation is responsible for:
- A Healthy Immune System
- Cellular Repair
- Neurotransmitter Production
People with MTHFR anomalies can be more susceptible to stress and less tolerant to toxic exposure.
Conditions associated with MTHFR polymorphism include but are not limited to:
- Breast cancer
- Frequent miscarriages
- Infertility (male and female)
- Depression & Anxiety (neurotransmitter deficiency)
- Bi Polar Spectrum Disorder
- Heart Attack and Atherosclerosis
- Down’s Syndrome
The good news is that you can be tested for this gene mutation and there are many supplements that can help you naturally compensate. The tricky part is there is over-methylation and under-methylation, so what’s good for one person may be bad for another. For this reason, it’s very important to work with a health care professional to determine the right plan for you. This is not the case for me, but many people with these polymorphisms are very sensitive to supplements, which only further complicates treatment protocol.
THE POINT: From now on I’m going to suggest testing to any clients with the above conditions OR who show elevated homocysteine or low estrogen metabolites on their blood tests. Also, for any clients who have IBS, chemical sensitivity, Fibromyalgia, Chronic Fatigue Syndrome, MS, Parkinson’s, Cervical Dysplasia, Infertility, drug sensitivities or family history of cancer, strokes, embolisms, heart attacks, clots or essential hypertension.
There is a relatively simple solution for MTHFR gene mutations yet gone undiagnosed . . . there is the potential for great imbalance and distress.
The power lies in your hands . . . go get tested and/or reach out to me for support!
In devotion to your health and happiness,
- Understanding the Implications of MTHFR Gene Mutation - October 31, 2019
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- Biggest Test of My Beliefs-Ever - October 16, 2019
- 3 Kinds of Thoughts That Stress You out (And Shrink Your Brain) - December 6, 2018
- Is This Weighing down Your Brain? - October 30, 2018
- You’ll Never Find Balance Without This - October 29, 2018
- It Hit Me like a Ton of Bricks and I Had to Do It - October 8, 2018
- You Are Not Your Results - August 15, 2018